Essentially, the cobblestone pattern is quite similar to the globular one but is composed of closely aggregated, larger, somewhat angulated globules resembling a cobblestone.

Diagnostic significance

The cobblestone pattern is found in papillomatous dermal nevi (Unna nevus), in congenital nevi, and sometimes in the dermal part of compound Clark nevi. Furthermore, in rare instances this particular pattern is also observed in seborrheic keratosis.