Diffuse hypopigmented areas are sometimes found in Clark nevi and should be differentiated from malignant melanomas with regression

This Clark nevus is characterized by a patchy reticular pattern and localized multifocal hypopigmentation

There is localized focal hypopigmentation within the center of an otherwise rather typical Clark nevus

The localized focal hypopigmentation dermoscopically seen within this compound Clark nevus might be explained by the rather delicate pigmentation of rete ridges and the nearly complete absence of pigmented nests of melanocytes and melanophages in the papillary dermis within the encircled area