Melanoma simulating Clark nevus
Early invasive melanoma exhibiting light-brown diffuse pigmentation with few irregular dots/globules basically compatible also with Clark nevus
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Melanoma simulating Reed nevus
Heavily pigmented melanoma revealing streaks at the periphery arranged along the whole ircumference, reminescent of the starburst pattern commonly found in Reed nevi
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Melanoma simulating Spitz nevus
In this example of early invasive melanoma the globular pattern with hints of a blue-whitish veil is suggestive of a Spitz nevus, globular type
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Melanoma simulating blue nevus
Note the few irregular dots/globules within this otherwise homogeneously blue-gray pigmented lesion.
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Melanoma simulating combined nevus
The localized, gray-bluish pigmentation corresponding to a pigmented cluster of atypical melanocytes within this hypomelanotic melanoma may be easily interpreted as a combined nevus.
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Melanoma simulating Unna nevus
Nodular melanoma resembling Unna nevus due to the presence of exophytic papillary structures. The few irregular dots/globules are the only clue for a correct diagnosis
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Melanoma simulating Miescher nevus
Diffuse pigmentation and rare comedo-like openings are suggestive for Miescher nevus in this otherwise featureless nodular melanoma.
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Melanoma simulating recurrent nevus
In this persistent melanoma a light-brown to gray-reddish diffuse pigmentation is visible adjacent to a surgical scar. Nearly identical dermoscopic features are commonly found in recurrent nevi.
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Melanoma simulating reticulated lentigo
In the absence of other melanoma-specific dermoscopic criteria, the atypical pigment network structures of this irregularly outlined lesion may easily lead astray to the diagnosis of reticulated lentigo.
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Melanoma simulating actinic lentigo
Melanoma in situ (lentigo maligna) exhibiting a quite typical pigment network with only focal irregular pigmentation. Because of its irregular outline and rather sharp circumscription, this lesion may be diagnosed as an actinic lentigo.
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Melanoma simulating basal cell carcinoma
Hypomelanotic melanoma simulating basal cell carcinoma due to the presence of more or less irregularly outlined brownish-gray areas resembling leaf-like areas. Also the vascular structures, albeit not arborizing, may erroneously confirm the diagnosis of basal cell carcinoma
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Melanoma simulating seborrehic keratosis
Melanoma in situ of the face (lentigo maligna) resembling a reticulated type of seborrheic keratosis. Note the delicate annular-granular structures representing the only clue for a correct diagnosis.
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Melanoma simulating seborrehic keratosis
This verrucous melanoma was interpreted as an acanthotic type of seborrheic keratosis because of the presence of numerous comedo-like openings. The lesion was removed only because the patient, a physician himself, insisted on the surgical excision.
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Melanoma simulating hemangioma
This melanoma can be easily missed because the numerous red globules resembling red lacunas are suggestive of hemangioma. The blue-whitish veil clearly visible within this lesion was not assessed as a melanoma-specific criterion because of the association with the pretended red lacunas
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Melanoma simulating pyogenic granuloma
Note the hemorrhagic crust somehow mimicking red lacunas that in the absence of melanoma-specific dermoscopic criteria was leading to the diagnosis of pyogenic granuloma
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Featureless melanoma
A particular type of melanoma devoid of any distinctive dermoscopic criteria has been called featureless melanoma’ by Menzies [Arch Dermatol 1996]. Only because this lesion was not diagnostic at all, was a diagnostic excision performed.
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