Melanoma simulating Clark nevus
Early invasive melanoma exhibiting light-brown diffuse pigmentation with few irregular dots/globules basically compatible also with Clark nevus

Melanoma simulating Reed nevus

Heavily pigmented melanoma revealing streaks at the periphery arranged along the whole ircumference, reminescent of the starburst pattern commonly found in Reed nevi

Melanoma simulating Spitz nevus

In this example of early invasive melanoma the globular pattern with hints of a blue-whitish veil is suggestive of a Spitz nevus, globular type

Melanoma simulating blue nevus

Note the few irregular dots/globules within this otherwise homogeneously blue-gray pigmented lesion.

Melanoma simulating combined nevus

The localized, gray-bluish pigmentation corresponding to a pigmented cluster of atypical melanocytes within this hypomelanotic melanoma may be easily interpreted as a combined nevus.

Melanoma simulating Unna nevus

Nodular melanoma resembling Unna nevus due to the presence of exophytic papillary structures. The few irregular dots/globules are the only clue for a correct diagnosis

Melanoma simulating Miescher nevus

Diffuse pigmentation and rare comedo-like openings are suggestive for Miescher nevus in this otherwise featureless nodular melanoma.

Melanoma simulating recurrent nevus

In this persistent melanoma a light-brown to gray-reddish diffuse pigmentation is visible adjacent to a surgical scar. Nearly identical dermoscopic features are commonly found in recurrent nevi.

Melanoma simulating reticulated lentigo

In the absence of other melanoma-specific dermoscopic criteria, the atypical pigment network structures of this irregularly outlined lesion may easily lead astray to the diagnosis of reticulated lentigo.

Melanoma simulating actinic lentigo

Melanoma in situ (lentigo maligna) exhibiting a quite typical pigment network with only focal irregular pigmentation. Because of its irregular outline and rather sharp circumscription, this lesion may be diagnosed as an actinic lentigo.

Melanoma simulating basal cell carcinoma

Hypomelanotic melanoma simulating basal cell carcinoma due to the presence of more or less irregularly outlined brownish-gray areas resembling leaf-like areas. Also the vascular structures, albeit not arborizing, may erroneously confirm the diagnosis of basal cell carcinoma

Melanoma simulating seborrehic keratosis

Melanoma in situ of the face (lentigo maligna) resembling a reticulated type of seborrheic keratosis. Note the delicate annular-granular structures representing the only clue for a correct diagnosis.

Melanoma simulating seborrehic keratosis

This verrucous melanoma was interpreted as an acanthotic type of seborrheic keratosis because of the presence of numerous comedo-like openings. The lesion was removed only because the patient, a physician himself, insisted on the surgical excision.

Melanoma simulating hemangioma

This melanoma can be easily missed because the numerous red globules resembling red lacunas are suggestive of hemangioma. The blue-whitish veil clearly visible within this lesion was not assessed as a melanoma-specific criterion because of the association with the pretended red lacunas

Melanoma simulating pyogenic granuloma

Note the hemorrhagic crust somehow mimicking red lacunas that in the absence of melanoma-specific dermoscopic criteria was leading to the diagnosis of pyogenic granuloma

Featureless melanoma

A particular type of melanoma devoid of any distinctive dermoscopic criteria has been called featureless melanoma’ by Menzies [Arch Dermatol 1996]. Only because this lesion was not diagnostic at all, was a diagnostic excision performed.